the involvement of hippocampal ca3 trp channels in anxiety and avoidance memory consolidation in rats tested in elevated plus maze
نویسندگان
چکیده
in the current study, we assessed the role of transient receptor potential (trp) channels on avoidance memory and anxiety states in ca3 area of the hippocampus. we explored the anxiety and avoidance memory states using test-retest protocol in the elevated plus maze to understand whether trp channels can affect the above mentioned states in ca3 area. to investigate the consolidation phase of memory, the drugs were injected into the ca3 region before the test. our data showed that the application of skf-96365 did not alter anxiety-like behaviors but induced avoidance memory impairment. it was revealed that ca3 trp channels could affect the avoidance memory consolidation and their role must be considered in future research.
منابع مشابه
Modulation of Anxiety-Like Behavior in Sildenafil Citrate-Treated Mice Placed in an Elevated Plus-Maze
Introduction: Sildenafil, a phosphodiesterase-5 (PDE5) inhibitor, may have various effects on the central nervous system via the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway. Preclinical studies have shown the controversial effect of sildenafil on anxiety-like behavior in animals. This study was undertaken to investigate the acute effect of sildenafil on anxiety-like behavior...
متن کاملPrevious maze experience required to increase open arms avoidance in rats submitted to the elevated plus-maze model of anxiety.
Studies have shown an increased open arm avoidance in rats re-exposed to the elevated plus-maze (EPM), which suggests a qualitative shift in emotional states from an unconditioned (Trial 1) to a learned (Trial 2) form of fear response, but a precise source of aversion has not been determined. Using rats submitted to the EPM or various EPM-derived configurations, this study was designed to inves...
متن کاملanxiolytic effect of ocimum basilicum extract in rats tested by elevated plus-maze task
conclusions our results demonstrated that the extract of ob could induce anxiolytic effect in rats after 1 week oral administration. the effect of ob was not induced through changes in motor activity. further investigations are necessary for pharmacological providing of ob and better understanding of its anxiolytic properties and neurobiological mechanisms. results the results showed that after...
متن کاملthe translators agency and ideological manipulation in translation: the case of political texts in translation classes in iran
در این تحقیق به نقش واسطه ای مترجم در ایجاد تغییرات ایدئولوژیک در ترجمه متون سیاسی پرداخته شده است. بدین منظور محقق متنی سیاسی در خصوص ادعاهای آمریکا در مورد برنامه هسته ای ایران را انتخاب کرد. این متن از سایت spacewar.com انتخاب شد که دارای ایدئولوژی مغرضانه در مورد برنامه هسته ای ایران است. سپس یک گروه 30 نفره از دانشجویان کارشناسی ارشدرشته مترجمی زبان انگلیسی دانشگاه شیخ بهایی انتخاب شدند. ا...
15 صفحه اولAn Assessment of Changes in Open-Field and Elevated Plus-Maze Behavior Following Heat Stress in Rats
This paper presents the effect of high environmental heat on behavior of the male Charles Foster rats. Eighty rats were divided into three groups, subjected to (i) acute heat stress (ii) chronic heat stress and (iii) handling control group. Animals were exposed to the hot environment in a biological oxygen demand incubator at 38 ± 1ºC (relative humidity 45-50%) for four hours of continuous sing...
متن کاملThe Effect of Scopolamine on Avoidance Memory and Hippocampal Neurons in Male Wistar Rats
Introduction: Cholinergic systems are involved in learning and memory. Scopolamine, a muscarinic acetylcholine receptor antagonist, is used as a standard/ reference drug for inducing cognitive deficits in healthy humans and animals. The purpose of this study was to evaluate the effects of scopolamine on avoidance memory and number of neurons in rat’s hippocampus. . Methods: Thirty five male alb...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of paramedical sciencesجلد ۷، شماره ۱، صفحات ۷-۱۲
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023